windows native library to change internet explorer proxy options. the compiled version is for x64 windows, if you need a 32 bit binary, compile it with the source code.

set proxy for internet explorer

Require module: PyQt5

usage:

python.exe .\setproxy.py --proxy 127.0.0.1:8118 --switch 0
python.exe .\setproxy.py --proxy 127.0.0.1:8118 --switch 1